Zika vaccine may be ready by the end of 2016

January 29, 2016, 9:51pm


Geovane Silva holds his son, Gustavo Henrique, who has microcephaly linked to the Zika virus, at the Oswaldo Cruz Hospital in Recife, Brazil, on Wednesday. Picture: REUTERS/UESLEI MARCELINO on BDLive

By Rod Nickel, Reuters on Business Day Live

WINNIPEG — A vaccine for the Zika virus, which has been linked to severe birth defects in thousands of infants, could be ready for emergency use before year-end, one of its lead developers said on Thursday, a timetable well ahead of estimates by US officials.

Canadian scientist Gary Kobinger, part of a consortium working on the vaccine, told Reuters in an interview that the first stage of testing on humans could begin as early as August.

If successful, that may allow the vaccine to be used during a public health emergency, in October or November.

"The first thing is to be ready for the worst," Mr Kobinger, who helped develop a trial vaccine that was successful in fighting Ebola in Guinea, said. "This vaccine is easy to produce. It could be cranked to very high levels in a really short time."

He did not say when it could be widely available.

The US had two potential candidates for a Zika vaccine and could begin clinical trials in people by the end of this year, but there would not be a widely available vaccine for several years, US officials said on Thursday.

The mosquito-transmitted virus has been linked to brain damage in thousands of babies in Brazil. There is no proven vaccine or treatment for Zika, a close cousin of dengue and chikungunya, which causes mild fever and rash. An estimated 80% of people infected have no symptoms, making it difficult for pregnant women to know whether they have been infected.

In Geneva, the World Health Organisation (WHO) said on Thursday that Zika was spreading "explosively" and could affect as many as 4-million people in the Americas.

Mr Kobinger, the lead scientist on this project from Quebec City’s Laval University and head of special pathogens at Canada’s National Microbiology Laboratory in Winnipeg, is working with the University of Pennsylvania, led by scientist David Weiner, Inovio Pharmaceuticals and South Korea’s GeneOne Life Science.

Inovio CE Joseph Kim said the timeline to make the vaccine available by the end of the year was aggressive, but possible.

"I believe this will be the first to go into human testing. We believe we’re ahead of the pack in the race for a Zika vaccine," he said in an interview.

Inovio shares on the Nasdaq jumped 7.6% on Thursday to close at $5.78.

Other vaccine candidates appear to be moving more slowly.

The Sao Paulo-based Butantan Institute said last week it planned to develop a vaccine "in record time", although its director warned this was still likely to take three to five years.

The candidate vaccine Mr Kobinger was working on mimicked the virus, triggering the body’s immune system, he said.

"When the real thing comes in, then the antibodies are there, the immune system is primed, it’s ready to attack right away," Mr Kobinger said.

Reuters